In order to elucidate the pyrazorone allergy of antipyrine, it was orally given to rabbits and a patch test was conducted.
It was discussed that the drug newly developed would be effective for patients of refractory cancer.
The reason is considered (explained) that because the surgery followed by subsequent radiation and chemotherapy were remarkably effective, neither recurrence nor metastasis was observed in these patients.
It was suggested that there was a possibility that the formulation might be effective since the effective concentration was observed in target tissue.
The effective blood concentration of the benzodiazepine to induce CYP3A4 was analyzed to be in the range between 0.1 to 0.7 μg/mL.